Editing Pharmacology – LPN Practice Questions (section)

==Question 10==
A client on isoniazid and rifampin for tuberculosis calls the clinic. Which report requires the nurse to notify the registered nurse or provider promptly?
# The urine and tears have turned orange
# Yellowing of the sclera with nausea, dark urine, and right upper quadrant discomfort
# A mild metallic taste in the mouth
# A request for the next appointment reminder

'''Answer:''' 2 (B) Yellowing of the sclera with nausea, dark urine, and right upper quadrant discomfort.

''Rationale:'' These findings suggest drug-induced hepatitis, a serious adverse effect of both isoniazid and rifampin, and require immediate reporting and liver function testing. Option 1 is the expected orange discoloration of body fluids from rifampin, which also permanently stains soft contact lenses and reduces the effectiveness of oral contraceptives. Options 3 and 4 are not urgent. Clients on isoniazid also receive pyridoxine, which is vitamin B6, to prevent peripheral neuropathy.